INFRAFRONTIER.GR is the Greek Research Infrastructure for phenotyping and archiving of model mammalian genomes.
The use of transgenic mouse models, i.e. mice with modified genetic material resulting in enhancement or suppression of the expression of genes of interest, has proven to be invaluable both for understanding basic biological principles, as well as for revealing mechanisms of disease. Numerous diseases, such as rheumatoid arthritis, cancer, multiple sclerosis and others, have been modeled in mice to date, such that they are similar both in etiology and function to their human equivalent, allowing scientists to screen and test new drugs for their diagnosis and treatment. The rapid technical developments of the last decade in genetic engineering, together with a shift towards large scale functional genomics projects, has already resulted in a very large number of transgenic animal models of various diseases, offering a unique opportunity for new drug development. An essential task for biomedical sciences in the 21st century will be the generation of mouse mutations for every gene in the mouse genome, creating a vital resource of models for the study of human disease. The functional analysis of mammalian genomes drives the new era of genomic and personalized medicine. In this context, Research Infrastructures (RIs) exploiting the mouse as a disease model constitute pillars for biotechnological and clinical innovation.
INFRAFRONTIER is the ESFRI infrastructure for archiving and phenotyping model mammalian genomes. INFRAFRONTIER aims to build a world-class research infrastructure that provides the biomedical research community with the tools needed to unravel the role of gene function in human disease.
INFRAFRONTIER aims to:
Provide access to mouse models, data, and scientific platforms and services to study the functional role of the genome in human health and disease.
Archive and distribute scientifically valuable mouse strains through the European Mouse Mutant Archive (EMMA), one of the worlds leading mouse repositories.
Provide access to a whole-organism, systemic analysis of genotype-phenotype interactions using cutting-edge analytical and diagnostic methodology in the INFRAFRONTIER mouse clinics.
Provide bottom-up access for individual scientists and research groups and top-down capacities for large-scale international initiatives such as the International Mouse Phenotyping Consortium (IMPC).
InfrafrontierGR is the Greek node of INFRAFRONTIER. InfrafrontierGR provides a sustainable, open access pan-Hellenic Research Infrastructure (RI) that aims to increase local competitiveness in translational medicine via the generation, distribution and disease-oriented phenotyping of mutant mouse genomes. Since 2009, InfrafrontierGR coordinator Fleming is also a full member of INFRAFRONTIER's archiving node, the European Mutant Mouse Archive (EMMA), a non-profit repository for the collection, archiving (via cryopreservation) and distribution of mutant mouse strains essential for basic biomedical research. The comprehensive physical and data resources of EMMA support basic biomedical and preclinical research, and the available research tools and mouse models of human disease offer the opportunity to develop a better understanding of molecular disease mechanisms and may provide the foundation for the development of diagnostic, prognostic and therapeutic strategies.
More than 135 Million Euros have already been committed for the construction, upgrading and operation of the national facilities contributing to the pan-European INFRAFRONTIER Research Infrastructure in Germany, France, Czech Republic, Greece, Finland, Austria, Spain and Italy. Greece, through the General Secretariat for Research and Technology, has committed 3,9 million Euros for the implementation of the Greek node of Infrafrontier, InfrafrontierGR.
Ιn December 2013, InfrafrontierGR coordinator, Fleming, became founding member of Infrafrontier GmbH, the legal entity that was created to coordinate the transnational activities of the INFRAFRONTIER Research Infrastructure. It is seated in Germany at the Helmholtz Zentrum München.
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The INFRAFRONTIER GmbH provides central access to all the services of the INFRAFRONTIER Research Infrastructure via the INFRAFRONTIER website. It improves access for the users of the INFRAFRONTIER Research Infrastructure by building capacities for systemic phenotyping, archiving and distribution of mouse models and by providing an efficient and transparent access process, based on peer-evaluated scientific excellence.
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