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PUBLICATIONS

List of publications supported by InfrafrontierGR/Phenotypos 

(those marked with * are from external groups (i.e. corresponding author not part of the InfrafrontierGR working team)

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  1. Armaka M, Ospelt C, Pasparakis M, Kollias G. (2018) Nat Commun., 9(1):618. The p55TNFR-IKK2-Ripk3 Axis Orchestrates Arthritis by Regulating Death and Inflammatory Pathways in Synovial Fibroblasts. [https://www.nature.com/articles/s41467-018-02935-4]

  2. Sakkou M, Chouvardas P, Ntari L, Prados A, Moreth K, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Denis MC, Karagianni N, Kollias G. (2018) JCI Insight, 3(7):e98864. Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosis. [https://pubmed.ncbi.nlm.nih.gov/29618659/]

  3. Ntari L, Sakkou M, Chouvardas P, Mourouzis I, Prados A, Denis MC, Karagianni N, Pantos C, Kollias G. (2018) Ann Rheum Dis., 77(6):926-934. Comorbid TNF-mediated Heart Valve Disease and Chronic Polyarthritis Share Common Mesenchymal Cell-Mediated Aetiopathogenesis [https://pubmed.ncbi.nlm.nih.gov/29475857/]

  4. Christodoulou-Vafeiadou E, Ioakeimidis F, Andreadou M, Giagkas G, Stamatakis G, Reczko M, Samiotaki M, Papanastasiou AD, Karakasiliotis I, Kontoyiannis DL. (2018) Front Immunol., 9:2732. Divergent Innate and Epithelial Functions of the RNA-Binding Protein HuR in Intestinal Inflammation [https://pubmed.ncbi.nlm.nih.gov/30532756/]

  5. Henriques A, Koliaraki V and Kollias G. (2018) PNAS, 115(24): E5546-E5555 Mesenchymal MAPKAPK2/HSP27 drives intestinal carcinogenesis. [https://pubmed.ncbi.nlm.nih.gov/29844172/]

  6. Koliaraki V, Chalkidi N, Henriques A, Tzaferis C, Polykratis A, Waisman A, Muller W, Hackam DJ, Pasparakis M, Kollias G. (2019) Cell Rep., 26(3):536-545.e4. Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis. [https://pubmed.ncbi.nlm.nih.gov/30650348/]

  7. *Kerdidani D, Chouvardas P, Arjo AR, Giopanou I, Ntaliarda G, Guo YA, Tsikitis M, Kazamias G, Potaris K, Stathopoulos GT, Zakynthinos S, Kalomenidis I, Soumelis V, Kollias G, Tsoumakidou M. (2019) Nat Commun., 10(1):1405. Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma. [https://pubmed.ncbi.nlm.nih.gov/30926812/]

  8. *Polykratis A, Martens A, Eren RO, Shirasaki Y, Yamagishi M, Yamaguchi Y, Uemura S, Miura M, Holzmann B, Kollias G, Armaka M, van Loo G, Pasparakis M. (2019) Nat Cell Biol., 21(6):731-742. A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain. [https://pubmed.ncbi.nlm.nih.gov/31086261/] 

  9. *Spella M, Lilis I, Pepe MA, Chen Y, Armaka M, Lamort AS, Zazara DE, Roumelioti F, Vreka M, Kanellakis NI, Wagner DE, Giannou AD, Armenis V, Arendt KA, Klotz LV, Toumpanakis D, Karavana V, Zakynthinos SG, Giopanou I, Marazioti A, Aidinis V, Sotillo R, Stathopoulos GT. (2019) E-life, 8:e45571. Club Cells Form Lung Adenocarcinomas and Maintain the Alveoli of Adult Mice. [https://pubmed.ncbi.nlm.nih.gov/31140976/]

  10. *Martens A, Priem D, Hoste E, Vetters J, Rennen S, Catrysse L, Voet S, Deelen L, Sze M, Vikkula H, Slowicka K, Hochepied T, Iliaki K, Wullaert A, Janssens S, Lamkanfi M, Beyaert R, Armaka M, Bertrand MJM, van Loo G. (2020) Nat Immunol., 21(4):381-387. Two Distinct Ubiquitin-Binding Motifs in A20 Mediate Its Anti-Inflammatory and Cell-Protective Activities.  [https://pubmed.ncbi.nlm.nih.gov/32205881/]

  11. *Gagliano T, Shah K, Gargani S, Lao L, Alsaleem M, Chen J, Ntafis V, Huang P, Ditsiou A, Vella V, Yadav K, Bienkowska K, Bresciani G, Kang K, Li L, Carter P, Benstead-Hume G, O'Hanlon T, Dean M, Pearl FM, Lee SC, Rakha EA, Green AR, Kontoyiannis DL, Song E, Stebbing J, Giamas G. (2020) J Clin Invest., 130(6):3188-3204. PIK3Cδ expression by fibroblasts promotes triple-negative breast cancer progression. [https://www.ncbi.nlm.nih.gov/pubmed/32125284]

  12. *Gioulbasani M, Galaras A, Grammenoudi S, Moulos P, Dent AL, Sigvardsson M, Hatzis P, Kee BL, Verykokakis M. (2020) Nat Immunol., 21(9):1058-1069. The transcription factor BCL-6 controls early development of innate-like T cells. [https://pubmed.ncbi.nlm.nih.gov/32719520/]

  13. Christodoulou-Vafeiadou E, Geka C, Ntari L, Kranidioti K, Argyropoulou E, Meier F, Armaka, M Mourouzis I, Pantos C, Rouchota M, Loudos G, Denis MC, Karagianni N & Kollias G. (2020) Arthritis Res Ther., 22(1):232. Ectopic bone formation and systemic bone loss in a transmembrane TNF-driven model of human spondyloarthritis. [https://pubmed.ncbi.nlm.nih.gov/33023659/]

  14. Keramidis I, Vourkou E, Papanikolopoulou K, Skoulakis EMC. (2020) Front Mol Neurosci. 13:569520 Functional Interactions of Tau Phosphorylation Sites That Mediate Toxicity and Deficient Learning in Drosophila melanogaster. [https://pubmed.ncbi.nlm.nih.gov/33192295/]

  15. *Stamatakis G, Samiotaki M, Mpakali A, Panayotou G, Stratikos E (2020) J. Proteome Res.,  19(11):4398–4406. Generation of SARS-CoV-2 S1 Spike Glycoprotein Putative Antigenic Epitopes in Vitro by Intracellular Aminopeptidases. [https://pubs.acs.org/doi/full/10.1021/acs.jproteome.0c00457#]

  16. Prados A, Onder L, Cheng HW, Mörbe U, Lütge M, Gil-Cruz C, Perez-Shibayama C, Koliaraki V, Ludewig B, Kollias G (2021) Nat Immunol., 22:510–519. Fibroblastic reticular cell lineage convergence in Peyer’s patches governs intestinal immunity. [https://www.nature.com/articles/s41590-021-00894-5] 

  17. Ntari L, Nikolaou C, Kranidioti K, Papadopoulou D, Christodoulou-Vafeiadou E, Chouvardas P, Meier F, Geka C, Denis MC, Karagianni N, Kollias G (2021) J Transl Med., 19:165 Combination of subtherapeutic anti-TNF dose with dasatinib restores clinical and molecular arthritogenic profiles better than standard anti-TNF treatment. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063445/]

  18. Subramanian P, Gargani S, Palladini A, Chatzimike M, Grzybek M, Peitzsch M, Papanastasiou AD, Pyrina I, Ntafis V, Gercken B, Lesche M, Petzold A, Sinha A, Nati M, Thangapandi VR, Kourtzelis I, Andreadou M, Witt A, Dahl A, Burkhardt R, Haase R, Domingues AMJ, Henry I, Zamboni N, Mirtschink P, Chung KJ, Hampe J, Coskun Ü, Kontoyiannis DL, Chavakis T (2021) Hepatology, 75(4):881-897. The RNA binding protein human antigen R is a gatekeeper of liver homeostasis. [https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.32153]

  19. Birladeanu, AM., Rogalska, M., Potiri, M. et al. The scaffold protein IQGAP1 links heat-induced stress signals to alternative splicing regulation in gastric cancer cells (2021) Oncogene, 40:5518–5532. The scaffold protein IQGAP1 links heat-induced stress signals to alternative splicing regulation in gastric cancer cells. [https://www.nature.com/articles/s41388-021-01963-7#citeas]

  20. *Ehlich H, Cater HL, Flenniken AM, Goncalves Da Cruz I, Mura AM, Ntafis V, Raess M, Selloum M, Stoeger C, Suchanova S, Vuolteenaho R, Brown SDM, Hérault Y, Hinttala R, Hrabě de Angelis M, Kollias G, Kontoyiannis DL, Malissen B, McKerlie C, Sedláček R, Wells SE, Zarubica A, Rozman J, Sorg T. (2021) Mamm Genome, 33(1):120-122. INFRAFRONTIER quality principles in systemic phenotyping. [https://pubmed.ncbi.nlm.nih.gov/34328547/]

  21. Nanou A, Bourbouli M, Vetrano S, Schaeper U, Ley S, Kollias G (2021) Cell Reports, 35(8):109168. Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis. [https://www.sciencedirect.com/science/article/pii/S2211124721005106]

  22. Papadopoulou, Dimitra, Antonios Drakopoulos, Panagiotis Lagarias, Georgia Melagraki, George Kollias, and Antreas Afantitis (2021) Int. J. Mol. Sci., 22(19):10220. In Silico Identification and Evaluation of Natural Products as Potential Tumor Necrosis Factor Function Inhibitors Using Advanced Enalos Asclepios KNIME Nodes. [https://www.mdpi.com/1422-0067/22/19/10220]

  23. Georganta EM, Moressis A, Skoulakis EMC. (2021) J Neurosci., 41(24):5274-5286. Associative Learning Requires Neurofibromin to Modulate GABAergic Inputs to Drosophila Mushroom Bodies. [https://pubmed.ncbi.nlm.nih.gov/33972401/]

  24. *Poutoglidou F, Pourzitaki C, Manthou ME, Samoladas E, Saitis A, Malliou F, Kouvelas D. (2021) Inflammopharmacol., 29:661–672. Infliximab prevents systemic bone loss and suppresses tendon inflammation in a collagen-induced arthritis rat model. [https://link.springer.com/article/10.1007/s10787-021-00815-w]

  25. *Voutyraki C, Choromidis A, Theodorou V, Efraimoglou C, Anagnostopoulos G, Magadi SS, Grammenoudi S, Zacharioudaki E, Delidakis C. (2021) Int J Dev Biol., 66(1-2-3):211-222. Repression of differentiation genes by Hes transcription factors fuels neural tumour growth in Drosophila. [https://pubmed.ncbi.nlm.nih.gov/34881794/]

  26. Melissari MT, Henriques A, Tzaferis C, Prados A, Sarris ME, Chalkidi N, Mavroeidi D, Chouvardas P, Grammenoudi S, Kollias G, Koliaraki V. (2022) Cell. Mol. Life Sci., 79(1): 1. Col6a1+/CD201+ mesenchymal cells regulate intestinal morphogenesis and homeostasis. [https://link.springer.com/article/10.1007/s00018-021-04071-7#citeas]

  27. *Poutoglidou F, Pourzitaki C, Manthou ME, Samoladas E, Saitis A, Malliou F & Kouvelas D. (2022) Connect Tissue Res., 63(6):577-589. The inhibitory effect of tocilizumab on systemic bone loss and tendon inflammation in a juvenile Collagen-Induced arthritis rat model. [https://doi.org/10.1080/03008207.2022.2042275]

  28. Gargani S, Lourou N, Arapatzi C, Tzanos D, Saridaki M, Dushku E, Chatzimike M, Sidiropoulos ND, Andreadou M, Ntafis V, Hatzis P, Kostourou V, Kontoyiannis DL. (2022) Front Immunol., 13:752215. Inactivation of AUF1 in Myeloid Cells Protects From Allergic Airway and Tumor Infiltration and Impairs the Adenosine-Induced Polarization of Pro-Angiogenic Macrophages [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873154/]

  29. Armaka M, Konstantopoulos D, Tzaferis C, Lavigne MD, Sakkou M, Liakos A, Sfikakis PP, Dimopoulos MA, Fousteri M, Kollias G. (2022) Genome Med., 14(1):78. Single-cell multimodal analysis identifies common regulatory programs in synovial fibroblasts of rheumatoid arthritis patients and modeled TNF-driven arthritis. [https://pubmed.ncbi.nlm.nih.gov/35879783/]

  30. Roumelioti F, Tzaferis C, Konstantopoulos D, Papadopoulou D, Prados A, Sakkou M, Liakos A, Chouvardas P, Meletakos T, Pandis Y, Karagianni N, Denis M, Fousteri M, Armaka M, Kollias G. (2022) bioRxiv, 2022.07.22.500939. miR-221/222 drive synovial fibroblast expansion and pathogenesis of TNF-mediated arthritis. [https://www.biorxiv.org/content/10.1101/2022.07.22.500939v1]

  31. Papadopoulou D, Roumelioti F, Tzaferis C, Chouvardas P, Pedersen AK, Charalampous F, Christodoulou-Vafeiadou E, Ntari L, Karagianni N, Denis M, Olsen JV, Matralis AN , Kollias G. (2022) bioRxiv, 2022.08.02.500956. Repurposing of Amisulpride, a known antipsychotic drug, to target synovial fibroblasts activation in arthritis. [https://www.biorxiv.org/content/10.1101/2022.08.02.500956v1]

  32. *Martens A, Hertens P, Priem D, Rinotas V, Meletakos T, Gennadi M, Van Hove L, Louagie E, Coudenys J, De Muynck A, Gaublomme D, Sze M, van Hengel J, Catrysse L, Hoste E, Zajac JD, Davey RA, Van Hoorebeke L, Hochepied T, Bertrand MJM, Armaka M, Elewaut D, van Loo G. (2022) EMBO Rep., 23(12):e55233. A20 controls RANK-dependent osteoclast formation and bone physiology. [https://pubmed.ncbi.nlm.nih.gov/36194667/]

  33. *Elhai, M., Micheroli, R., Houtman, M. et al. The long non-coding RNA HOTAIR contributes to joint-specific gene expression in rheumatoid arthritis. Nat Commun 14, 8172 (2023). https://doi.org/10.1038/s41467-023-44053-w 

  34. Christodoulou-Vafeiadou E, Geka C, Iliopoulou L, Ntari L, Denis MC, Karagianni N, Kollias G. A Novel human IL-23A Overexpressing Mouse Model of Systemic Lupus Erythematosus bioRxiv 2023.11.08.566163. [https://doi.org/10.1101/2023.11.08.566163]

  35. Papadaki V, Erpapazoglou Z, Kokkori M, Rogalska ME, Potiri M, Birladeanu A, Tsakiri EN, Ashktorab H, Smoot DT, Papanikolopoulou K, Samiotaki M, Kafasla P. IQGAP1 mediates the communication between the nucleus and the mitochondria via NDUFS4 alternative splicing. NAR Cancer. 2023 Aug 24;5(3):zcad046. [https://doi.org/10.1093/narcan/zcad046]

  36. *Karampitsakos, T., Galaris, A., Chrysikos, S. et al. Expression of PD-1/PD-L1 axis in mediastinal lymph nodes and lung tissue of human and experimental lung fibrosis indicates a potential therapeutic target for idiopathic pulmonary fibrosis. Respir Res 24, 279 (2023). [https://doi.org/10.1186/s12931-023-02551-x]

  37. *Voutyraki C, Choromidis A, Meligkounaki A, Vlachopoulos NA, Theodorou V, Grammenoudi S, Athanasiadis E, Monticelli S, Giangrande A, Delidakis C, Zacharioudaki E. Growth deregulation and interaction with host hemocytes contribute to tumor progression in a Drosophila brain tumor model. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2221601120. doi: 10.1073/pnas.2221601120. [https://doi.org/10.1073/pnas.2221601120]

  38. Iliopoulou, L., Tzaferis, C., Prados, A., Roumelioti, F., Koliaraki, V., & Kollias, G. (2023) Cellular complexity and crosstalk in murine TNF-dependent ileitis: Different fibroblast subsets propel spatially defined ileal inflammation through TNFR1 signalling. bioRxiv, 2023-09. [https://www.biorxiv.org/content/10.1101/2023.09.29.560107v1.abstract]

  39. Rinotas, V., Iliaki, K., Pavlidi, L., Meletakos, T., Mosialos, G., & Armaka, M. (2023). Cyld aborts hyperactivation of synovial fibroblasts in inflammatory arthritis by regulating the TAK1/IKK2 signaling axis. bioRxiv, 2023-11. [https://www.biorxiv.org/content/10.1101/2023.11.13.566552.abstract]

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