INFRAFRONTIER-GR OPEN CALL FOR PROPOSALS - Free of charge mouse microPET/CT services

InfrafrontierGR/PHenotypos provides free access to state-of-the-art mouse phenotyping services. microPET/CT imaging, image analysis and animals hosting for the whole period of imaging will be offered for two groups of mice.

Context and aim of the call

InfrafrontierGR/Phenotypos (www.infrafrontier.gr) is the Greek Research Infrastructure for the Molecular, Behavioral and Phenotypic Analysis of Mouse Models for Human Chronic Degenerative Diseases. The infrastructure provides access to first-class expertise and tools for biomedical research, offering cutting edge technological platforms and standardized pipelines for disease-oriented mouse phenotyping, as well as the generation, archiving and distribution of mouse mutants through the Greek node of the European Mouse Mutant Archive (EMMA).
The objective of this Call is to provide free access to state-of-the-art mouse PET/CT imaging services to the Greek biomedical research community to monitor disease activity and treatment response. InfrafrontierGR services offered through this Call include:

1. PET/CT imaging of mouse models and image analyis
2. Mouse Hosting

For more information, including eligibility criteria, selection procedure, application instructions and application form, please see the Full Call text below.

Deadline for submissions: 31/12/2020

Trans-Regional Access (TA) activity of the InfrafrontierGR/Phenotypos project
Free-of-charge mouse phenotyping services

The InfrafrontierGR/Phenotypos project (www.infrafrontier.gr) supports eligible researchers with free-of-charge mouse phenotyping services implemented as a Trans-regional Access activity. microPET/CT imaging, image analysis and animals hosting for the whole period of imaging will be offered for two groups of mice (control and diseased animals).
The services offered will be run by BRFAA InfrafrontierGR Units and may involve one of the following assays:

1. PET/CT imaging of mouse models

a. Oncological 3D imaging and image analysis
b. Cardiovascular 3D imaging and image analysis
c. Brain 3D imaging and image analysis
Deatails of the analysis can be found at the end of this document for technical specifications

2. Mouse Hosting

a. Long-term hosting of animals at IVC rack
● A collaboration agreement will be established between the successful applicants and BRFAA.
● All assays will be performed based on InfrafrontierGR Standard Operating Procedures.
● Results will be made available to successful applicants within a maximum of 3 months following provision of all required information and material.

Cost:

Access to the InfrafrontierGR/Phenotypos mouse phenotyping services under this Call is free of charge, with the exception of shipment costs of the mice to/from their centre, which must be covered by the applicant.

Eligibility:

Applications for this Call can be submitted by Researchers based anywhere in Greece. Members of the InfrafrontierGR/Phenotypos infrastructure are not eligible for applying.

Applications:
Applications for the Call are made via the following application form, which must be sent electronically to infrafrontierGR@fleming.gr by 31/12/2020. The form includes a short description of the project focusing on research plans for utilising the assay results plus the impact of the mouse model under investigation.

Selection procedure:

Proposals will be subject to a review procedure which will be initiated after the Call for applications is closed. Criteria for evaluation include scientific merit and soundness of the proposal, experience of the applicants, quality of preliminary data, feasibility of implementation, research plans and the impact/prospects for exploitation of the phenotyping data. A mixed panel of members of InfrafrontierGR/Phenotypos and potentially external evaluators will assess service requests supported by this activity. Applicants will be informed of the outcome of the evaluation within 6 weeks after the Call deadline. In a further step, experts of InfrafrontierGR Units will assess the technical feasibility of projects.
The technical evaluation of projects may require the provision of additional data such as:
- Information about mouse models
- Information on the genetic modification of your mutant mouse line if applicable
- Description of DNA modification
- Mutant phenotype(s), special housing or care requirements
- Current sanitary status
- Intellectual property rights (who generated and who owns the mouse line)

Acknowledgements:

Selected beneficiaries are obliged to acknowledge support under this scheme in all resulting publications using the following wording "We acknowledge support of this work by project InfrafrontierGR-Phenotypos (MIS 5002135), which is implemented under the Action Reinforcement of the Research and Innovation Infrastructure, is funded by the Operational Programme Competitiveness, Entrepreneurship and Innovation (NSRF 2014-2020) and is co-financed by Greece and the European Union (European Regional Development Fund)”.

Information/Contact:

C. D. Anagnostopoulos, Research Director
BRFAA Soranou Efessiou 4, 11527, Athens
Email. cdanagnostopoulos@bioacademy.gr
tel. 210 6597125

Anastasios Gaitanis, Research Scientist
BRFAA Soranou Efessiou 4, 11527, Athens
Email. agaitanis@bioacademy.gr
tel. 210 6597318

© 2014 INFRAFRONTIER.GR Project Management