InfrafrontierGR/Phenotypos

The InfrafrontierGR info WEBINAR provides an excellent opportunity to get acquainted with the open access service platforms that have been developed by the Infrastructure providing disease-oriented analyses of precision mutations.

As part of this one-day event participants will gain knowledge on:

1. Specialized platforms for clinical & biodiagnostic analysis of mouse models through:
• Clinical Imaging: Endoscopy, Ultrasound, Total and X-ray Micro-computed tomography (CT), Positron Emission Tomography (PET/CT)
• Hematology Analysis, Clinical Biochemistry, Specialized Cytometry Analysis and Cell sorting
• Histopathological and Immunohistochemical analysis with a range of optical devices
• Proteomic Diagnostics

2. Targeted preclinical evaluation pipelines for the development of diseases (and co-morbidities) of high clinical importance, such as:
• Inflammatory bowel disease
• Arthropathies
• Systemic and organ-specific infections
• Neurodegenerative diseases
• Liver and adipose tissue disorders
• Cancer

3. Archiving of mouse models through sperm and embryo cryopreservation and central distribution through the European Mouse Mutant Archive (EMMA)

4. Mutant Mouse Generation through Pronuclear Microinjection of DNA constructs, Blastocyst Injections of Mutated ESC Clones and CRISPR-Cas9 Genome Editing Technology