INFRAFRONTIER-GR/Phenotypos is an expansion of INFRAFRONTIER-GR, the Greek node of ESFRI Infrafrontier: The European Infrastructure for phenotyping and archiving model mammalian genomes. INFRAFRONTIER-GR is a sustainable, open access pan-Hellenic Research Infrastructure that provides access to mouse tools and resources necessary to unravel the role of gene function in human health and disease and to translate this knowledge into therapeutic approaches and disease prevention strategies. The Infrastructure offers services for the generation, distribution and disease-oriented phenotyping of mutant mouse genomes and is a full member of INFRAFRONTIER's archiving node, the European Mutant Mouse Archive (EMMA) - a major European biomedical repository that provides collection, archiving and distribution services of mutant mouse strains to the biomedical research community. INFRAFRONTIER-GR currently provides specialist secondary phenotyping services in the field of immunological diseases and cancer. In its next phase of development ("Phenotypos"), the Infrastructure will expand its current services to include: (a) macroscopic and analytical platforms for detailed description of complex disease phenotypes in mouse models that is required for the clinical/biomarker description of human disease; and (b) animal modeling and phenotyping of additional important disease areas in which Greek research is also highly competitive, including metabolic and neurological diseases.