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INFRAFRONTIER - OPEN Call - Model development and systemic phenotyping

INFRAFRONTIER - OPEN Call - Model development and systemic phenotyping

Main objective of the INFRAFRONTIER open call is to facilitate access for the wider biomedical research community to the unique infrastructure and scientific expertise of the participating mouse clinics. Mouse mutant lines can be tested through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human disease. Access will be granted on the basis of scientific excellence and supports the development and in depth characterisation of new mouse models for investigating gene function and human pathophysiology. INFRAFRONTIER will provide open access to all newly developed disease models and phenotyping data.

Scope and modalities

- Applications for the INFRAFRONTIER call can be submitted from scientists across the world. Access will be
granted based on scientific excellence and no regional restrictions will apply

- A total of 15 model development and phenotyping projects will be supported. Access is provided free of
charge and on a collaborative basis. The only costs to be borne by the applicants are shipment cost of
materials to and from the mouse clinics

- Participating mouse clinics are Phenomin-ICS, the Czech Centre for Phenogenomics (CCP), and the
German Mouse Clinic (GMC)

- Mouse models can be developed using either genome editing approaches (C57BL/6N genetic background
only) or by injecting targeted ES cells of the IKMC resource. Only new mouse models will be developed that
are not yet in the production pipelines of the International Mouse Phenotyping Consortium (IMPC, Alternatively, starting materials can also be a breeding nucleus or
cohorts ready for phenotyping (acceptance depending on health certificates). In the latter case mouse
mutants from various sources (transgenes, knockout mice, mutants from mutagenesis screens like ENU) and
of different genetic backgrounds can be accepted

- The phenotyping pipelines to be used will be either broad based primary phenotyping pipelines with a
possible customisation or the adult IMPC phenotype pipeline (

- Support will be provided by the mouse clinics to analyse and interpret the phenotype data

- A final report with all phenotype data will be prepared, and data will also be uploaded onto a public
phenotype database of the mouse clinics and / or onto the IMPC portal

- The generated mouse resources and phenotype data will be made available to the whole scientific
community. An optional grace period of up to 1 year for mouse resources and phenotype data may apply,
with immediate release of mouse resources and data after expiry of the grace period. Mouse mutant lines
will be deposited into the INFRAFRONTIER/EMMA repository for subsequent use by the scientific

Proposal submission

Send formal service requests with completed application form to
(informal enquiries prior to proposal submission also welcome)

Deadline for submission of proposals

15 February 2017

Evaluation process

16 February to 31 March 2017

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